Compounded Semaglutide + B12 + Glycine — Important Safety Information
GLP-1 receptor agonist with thyroid C-cell tumor warning, pancreatitis risk, and common GI side effects.
Compounded drugs are permitted to be prescribed under federal law, but are not FDA-approved and do not undergo FDA safety, effectiveness, or manufacturing review. Your EOS Health-affiliated provider may recommend certain doses of compounded semaglutide based on your medical evaluation.
Warning: Risk of Thyroid C-Cell Tumors
- In studies with mice and rats, semaglutide (the active ingredient in Wegovy and Ozempic) caused thyroid tumors, including thyroid cancer. Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.
- Do not use semaglutide if you or any of your family have ever had MTC, or have MEN 2.
What is semaglutide used for?
Semaglutide is a GLP-1 receptor agonist for chronic weight management, along with a reduced calorie diet and increased physical activity, for adults with BMI ≥30 (obesity) or ≥27 with at least one weight-related comorbid condition.
Limitations of Use:
- Should not be used in combination with other semaglutide-containing products or any other GLP-1 receptor agonist
- Safety/efficacy of coadministration with other weight loss products has not been established
- Not studied in patients with a history of pancreatitis
- Should not be used in patients with type 1 diabetes mellitus
Who should not use semaglutide?
- Personal or family history of MTC or MEN 2
- Known allergic reaction to semaglutide
How should semaglutide be administered?
Self-administered subcutaneous injection in the stomach, thigh, or upper arm once a week on the same day every week, with or without food. Refer to your treatment plan or your EOS Health-affiliated provider for detailed instructions.
What to tell your provider
Share all current medications. Watch for interactions with:
- Diabetes medications (insulin, sulfonylureas)
- Oral medications (semaglutide delays gastric emptying)
- Other GLP-1s (Wegovy, Ozempic, Saxenda, Victoza, Trulicity, Byetta, Bydureon)
- Other weight loss products and supplements
Share your full medical history, especially: type 1/2 diabetes, thyroid cancer, pancreatitis, kidney disease, diabetic retinopathy, depression, suicidal thoughts, ileus.
Pregnancy and breastfeeding
- Should not be used during pregnancy.
- Discontinue at least 2 months before a planned pregnancy.
- Was found in milk of lactating rats — tell your provider if breastfeeding.
Most serious side effects
If experiencing a medical emergency, call 911.
- Thyroid C-cell tumors (including MTC)
- Acute pancreatitis — severe abdominal pain
- Acute gallbladder disease
- Low blood sugar (hypoglycemia)
- Acute kidney injury from dehydration
- Serious allergic reactions
- Diabetic retinopathy complications
- Increased heart rate
- Suicidal behavior and ideation
- Never share needles or syringes
Most common side effects
- Nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, hypoglycemia in T2D, flatulence, gastroenteritis, GERD.
You are encouraged to report negative side effects to FDA MedWatch: www.fda.gov/medwatch or 1-800-FDA-1088.
Withholding or providing inaccurate information about your health and medical history in order to obtain treatment may result in harm, including, in some cases, death.
This information is not comprehensive. Please see the full Consumer Medical Information for complete safety information.