Compounded Semaglutide + B12 + Glycine

With a single weekly subcutaneous injection, semaglutide activates GLP-1 receptors to increase insulin response, regulate blood sugar, and reduce appetite — helping you feel full sooner and eat less without fighting constant cravings. Glycine is added to help maintain lean muscle mass during rapid weight loss. Cyanocobalamin (Vitamin B12) is included to help decrease nausea and support healthy energy production.

Your medication arrives as a bright pink solution in a multi-dose vial. Refrigerate it promptly upon arrival and keep it stored in the refrigerator between uses.

Each week, use a new insulin syringe to draw the prescribed amount and inject subcutaneously into the fatty tissue of your abdomen or thigh. Clean the rubber stopper with an alcohol swab before each draw, inject air into the vial equal to the volume you're withdrawing, then invert and pull back the plunger to fill the syringe.

Note: your vial will appear less than full — this is normal. Vials are designed to hold up to 5 mL but are filled with 0.5–2 mL of solution. Detailed instructions are included with your shipment, and your EOS Health clinician is available if you have questions.

Your prescribing clinician determines the right dose for you based on your health profile and goals. Doses are measured in units on an insulin syringe — for reference, 5 units equals 0.05 mL and 25 units equals 0.25 mL. Always follow the dosing instructions provided by your EOS Health provider, and reach out if anything is unclear before your first injection.

Semaglutide is injected on the same day each week. If you miss a dose, inject it as soon as possible — as long as it's within 5 days of your scheduled day. If more than 5 days have passed, skip the missed dose and resume your regular schedule the following week.

If you've missed doses for more than 2 consecutive weeks, contact your EOS Health clinician before resuming — a dose adjustment may be appropriate.

The most frequently reported side effect is nausea, particularly when starting treatment or after a dose increase. Injecting in the evening near bedtime can help you sleep through the worst of it. Constipation or diarrhea may also occur.

The B12 in this formulation is specifically included to help reduce nausea. If symptoms are severe or persistent, contact your EOS Health clinician — prescription anti-nausea medication is available when needed.

Semaglutide works best alongside meaningful lifestyle changes. A low-inflammatory diet — emphasizing fresh vegetables, fruits, omega-3s, and lean protein while limiting processed foods, refined carbohydrates, and saturated fats — can significantly amplify your results. Aim for 30–45 minutes of aerobic exercise and 10–25 minutes of resistance training four to five times per week.

Adequate protein intake is also essential to protect lean muscle during weight loss. If you're not seeing the progress you expect, connect with your EOS Health clinician to review your plan and explore adjustments.

A minimum of six months is recommended. This timeframe allows your body to reduce systemic inflammation, restore optimal insulin function, and establish sustainable metabolic patterns. Clinical studies suggest patients who combine semaglutide with lifestyle changes can lose 15% or more of their body weight over this period.

Your EOS Health clinician will work with you to determine the right duration based on your progress and goals.

This medication is contraindicated if you or a first-degree family member has been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2) or Medullary Thyroid Cancer. Inform your clinician if you have a history of pancreatitis, gallbladder disease, or Type 1 diabetes.

This medication should not be used during pregnancy or while breastfeeding. Discontinue at least two months before attempting to conceive. Your intake questionnaire and clinical review are designed to screen for these factors before treatment begins.

Compounded semaglutide used at EOS Health is prepared by FDA-registered, cGMP-certified compounding pharmacies. The active ingredient is sourced from domestic API manufacturers and does not contain a salt form attached to the molecule. Every compounded batch is sent to an independent, third-party testing facility to verify potency, sterility, and safety before shipment.

Your treatment is also supervised by a board-certified clinician from intake through your entire treatment journey — not just at the start.

No cause for concern. Compounded semaglutide has been verified to maintain full potency, sterility, and stability after exposure to room temperature and even elevated temperatures during transit. Refrigerate your vial promptly upon arrival and continue use as directed — the medication inside is unaffected.