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EOS Metabolic

Compounded Tirzepatide + B12

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Compounded Tirzepatide + B12 combines a once-weekly GLP-1 and GIP dual-agonist with vitamin B12 in a single injection. The tirzepatide acts on two hormone pathways involved in appetite and digestion, and B12 is included for its role in energy metabolism.

Key Features

Two-hormone mechanism: Tirzepatide acts on both the GLP-1 and GIP receptors, the pathways involved in satiety signaling and gastric emptying.

Vitamin B12 included: B12 has a role in red blood cell production and energy metabolism, and is built into the formulation rather than taken separately.

Appetite and fullness: Acts on the signals that regulate hunger and how long you feel full after eating.

Once-weekly dosing: One subcutaneous injection per week, with dosing set and adjusted by your clinician.

Blood sugar regulation: Influences insulin and glucagon signaling as part of how the medication acts on metabolism.

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Clinically proven. Personally delivered.

GLP-1 receptor agonists act on hormone pathways involved in appetite and digestion. Whether one fits you depends on your health history, current medications, and a licensed clinician's review — which is where every EOS protocol starts.

Beyond the scale

Steadier blood sugar, better energy, and improved metabolic markers come with the weight.

Clinically proven results

GLP-1 protocols backed by years of clinical data, with meaningful results for most patients within weeks.

Clinician-Supervised

Board-certified physicians review your intake, personalize your starting dose, and stay accessible throughout your treatment journey.

Once-Weekly Dosing

A single small injection per week. No daily pills, no complicated schedules — just one moment that fits into your routine.

Preserves lean muscle

The protocol favors fat loss while helping you hold onto the muscle that keeps you strong.

Preserves Lean Muscle

Unlike crash diets, GLP-1 therapy helps your body preferentially burn fat while maintaining the muscle mass that keeps you strong.

Common questions, answered.

Why is vitamin B12 added to compounded tirzepatide?

B12 is added to support energy metabolism during weight loss. As appetite drops and calorie intake falls on tirzepatide, some patients notice lower energy. Vitamin B12 plays a central role in red blood cell formation and in converting food into usable energy, so including it in each dose helps you stay active while the medication does its work.

Will the added B12 help with the fatigue some people feel on tirzepatide?

It can. Reduced food intake and rapid weight loss sometimes leave patients feeling run down, and low B12 levels make that worse. Compounding B12 into each weekly dose helps maintain healthy levels and supports steady energy. It is not a stimulant, and individual results vary from person to person.

Do I need a separate B12 shot with this formula?

No. The B12 is compounded directly into your weekly tirzepatide dose, so it is delivered in the same injection. There are no extra shots, vials, or schedules to manage. Your EOS clinician reviews your health history before prescribing to confirm the combined formula is right for you, and full details are in the Important Safety Information.

What happens if I'm not approved for the medication?

If you are not prescribed the desired medication from our team of medical providers, you will be notified and receive a full refund for all cost incurred. This includes a cancellation of any subscription memberships you selected.

What is the administration and dosage protocol?

EOS Health's approach to both oral and injectable tirzepatide administration involves a personalized dosage strategy. The medication starts at a lower dose and is gradually increased based on your body's response to minimize side effects. You will receive comprehensive instructions on how to self-administer the medication, ensuring comfort and confidence.

For oral tirzepatide:
- Administered using an oral syringe, which dispenses rather than injects.
- Measure the dose by pulling the plunger until you reach the appropriate volume as marked on the syringe, and administer it underneath the tongue.

You will receive comprehensive instructions on how to self-administer the medication, ensuring comfort and confidence in managing your medication. Regular follow-ups with your healthcare provider will help monitor your progress and adjust the dosage as needed to optimize your results and minimize side effects.

Disclaimer: Individual results may vary. Always consult with your healthcare provider before starting any new medication to ensure it is appropriate for your condition. Follow your healthcare provider's instructions for dosage and administration. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Not approved by the FDA for safety or efficacy. Prescription required.

How does tirzepatide work?

Tirzepatide activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, which help regulate blood sugar levels and reduce appetite.

Are there alternatives to compounded tirzepatide?

Yes, FDA-approved versions of tirzepatide—such as Mounjaro or Zepbound—should be considered as an alternative option.

What are common side effects of tirzepatide?

Common side effects of tirzepatide include nausea, vomiting, diarrhea, constipation, abdominal pain, decreased appetite, injection site reactions (such as redness, swelling, or pain), fatigue, and gastrointestinal issues like heartburn, gas, and bloating. Serious side effects, although less common, can include thyroid tumors, pancreatitis, and severe allergic reactions. Always consult your healthcare provider for personalized advice and to report any side effects.

Is compounded tirzepatide FDA-approved?

Compounded tirzepatide is not approved nor evaluated for safety, effectiveness, or quality by the FDA.

Brand-name medications such as Zepbound® (tirzepatide) and Mounjaro® (tirzepatide) are FDA-approved and not compounded. Compounded versions of tirzepatide are not affiliated with, endorsed by, approved by, or intended to replace the FDA-approved products manufactured by Eli Lilly.

How much weight can I lose on tirzepatide?

People lost an average of over 20% bodyweight in a 72-week clinical trial study of tirzepatide, but not without lifestyle changes. Along with a reduced calorie diet and increased exercise. In a 72-week clinical study of tirzepatide, adults with obesity and weight-related medical problems achieved 20.9% weight loss.

Can I start on a higher dosage?

If you're currently taking the medication and switching from another provider, you can choose to maintain your current dose, increase it, or decrease it. This information is asked during the ordering process to ensure you're purchasing the correct medication for you.

What is Compounded Tirzepatide?

Compounded tirzepatide is a medication created by licensed compounding pharmacies, customized for individual patient needs. It is prepared with tirzepatide and formulated to support healthy blood sugar regulation, weight management, and metabolic health. This medication works by mimicking the GLP-1 and GIP hormones, helping to regulate insulin release, lower glucagon levels, slow stomach emptying, and reduce appetite.

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HIPAA-compliant careU.S.-licensed cliniciansTransparent pricingFree expedited shippingEasy questionnaire100% OnlineNo insurance required