PT-141 Injection (Men) — Important Safety Information
Important safety information for PT-141 (bremelanotide) injection — blood pressure effects, common side effects, and who should not use it.
PT-141 (bremelanotide) prescribed through EOS Health is a compounded medication prepared by a U.S.-licensed 503A compounding pharmacy. Compounded drugs are not reviewed by the FDA for safety or effectiveness. This summary does not replace the guidance of your prescribing clinician.
How to use
PT-141 is given as a subcutaneous injection on an as-needed basis, taken ahead of anticipated sexual activity. Do not use more than one dose in any 24-hour period or more than eight doses per month. Use only as directed by your clinician.
Do not use if you
Have uncontrolled high blood pressure or known cardiovascular disease. PT-141 causes a transient increase in blood pressure and a decrease in heart rate after each dose, so it is not appropriate when a temporary rise in blood pressure could pose a risk.
Common side effects
The most common side effects are nausea, flushing, injection-site reactions, and headache. Nausea is most likely with the first few doses and tends to lessen over time.
Skin darkening (hyperpigmentation)
PT-141 can cause darkening of the skin, including on the face and gums. This is more likely with frequent use and in people with darker skin. Tell your clinician if you notice skin darkening.
Drug interactions
Tell your clinician about all medications you take. PT-141 may reduce the effectiveness of oral naltrexone. Combining PT-141 with medications that lower blood pressure should be discussed with your clinician first.
When to seek care
Stop use and contact your clinician or seek medical attention if you experience chest pain, a severe or persistent headache, a very high blood pressure reading, or any reaction that concerns you.