This medication is prepared by a licensed 503A compounding pharmacy and may only be dispensed pursuant to a valid, patient-specific prescription following an individualized medical evaluation. Compounded medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. Individual results vary.

EOS Women's Health

Biest 50:50 + Progesterone Topical Lotion

Compounded estrogen-plus-progesterone topical, in one application.

From

75.00

/ month

Formulation

Lock in bigger savings

Claim Offer

Your offer applies automatically at checkout — no code to enter.

This compounded topical lotion brings Biest (estradiol and estriol in a 50:50 ratio) together with progesterone in a single application, simplifying combination hormone therapy. It is used to relieve menopause symptoms such as hot flashes and night sweats, while the progesterone component helps protect the uterine lining and can support more restful sleep. Your EOS Health-affiliated clinician selects the combination that fits your symptoms and lab work.

Available strengths (Biest / progesterone): 0.25 mg / 10 mg · 0.5 mg / 20 mg · 1 mg / 50 mg

Key Features

Estrogen and Progesterone in One: Combines Biest (estradiol + estriol) with progesterone so combination therapy is a single daily application.

Relieves Menopause Symptoms: Helps ease hot flashes, night sweats, and mood changes tied to low estrogen.

Protects the Uterine Lining: The progesterone component helps counteract estrogen's effect on the uterus.

Supports Sleep and Comfort: Progesterone's calming effect pairs with estriol's support for vaginal and skin comfort.

Simplifies Your Routine: One lotion instead of separate estrogen and progesterone products.

Get started

Benefits

Your body. Your personalized plan.

Hormonal changes don't have to mean feeling like a different person. Clinician-guided hormonal balance therapy and women's longevity protocols are built around your symptoms, your labs, and your phase of life.

Balance for every phase

Hormone protocols tailored to your phase of life, from perimenopause through menopause.

Bone Density Support

Estrogen protocols that help preserve long-term skeletal health and reduce fracture risk as you age.

Physician Supervised

Board-certified providers monitor your labs and adjust your protocol continuously — no one-size-fits-all dosing.

Protects long-term health

Estrogen protocols also support bone density and cardiovascular health.

Relief beyond hot flashes

Support for the mood, sleep, and metabolic shifts that come with menopause.

Weight Management

Hormonal support to combat the metabolic changes that come with perimenopause and menopause.

FAQs

Common questions, answered.

What is Biest 50:50 + Progesterone lotion?

It is a compounded topical lotion that combines Biest (estriol and estradiol in a 50:50 ratio) with progesterone in a single application, pairing estrogen and progesterone in one step as part of a personalized hormone therapy plan.

How do I apply Biest + Progesterone lotion?

Apply the measured dose to clean, dry skin such as the inner arm or inner thigh, rotate sites, let it absorb, and wash your hands. Because it contains progesterone, which may cause drowsiness, many patients apply it in the evening.

What strengths does Biest + Progesterone lotion come in?

Available per-dose strengths pair Biest with progesterone at 0.25/10 mg, 0.5/20 mg, and 1/50 mg. Your clinician selects the combination that fits your plan.

Why combine estrogen and progesterone in one lotion?

Combining estrogen with progesterone in one lotion can simplify a combination hormone therapy routine, and progesterone helps protect the uterine lining when you have a uterus. Your clinician will confirm the combination is right for you.

How do I get started with Biest + Progesterone lotion?

Start by completing a free online visit. An EOS Health-affiliated clinician reviews your symptoms, health history, and any lab work, then determines whether treatment is appropriate before writing a prescription. If prescribed, your medication ships to your door.

Biest 50:50 + Progesterone Topical Lotion