This medication is prepared by a licensed 503A compounding pharmacy and may only be dispensed pursuant to a valid, patient-specific prescription following an individualized medical evaluation. Compounded medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. Individual results vary.

EOS Women's Health

Biest 50:50 Topical Lotion

Compounded bi-estrogen topical, personalized to your dose.

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75.00

/ month

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Biest 50:50 is a compounded topical lotion that pairs estradiol with estriol in a 50:50 ratio, combining the strength of estradiol with the gentler action of estriol. Applied to the skin and absorbed transdermally, it is used to relieve menopause symptoms such as hot flashes and night sweats and to support vaginal and skin comfort. Your EOS Health-affiliated clinician selects the concentration and dose that fit your symptoms and lab work.

Available strengths: 0.1% (0.25 mg or 0.5 mg per dose) / 0.2% (1 mg per dose)

Key Features

Two Estrogens, One Formula: Combines estradiol and estriol so you get the strength of estradiol alongside the gentler, short-acting effects of estriol.

Relieves Menopause Symptoms: Helps ease hot flashes, night sweats, and mood changes tied to low estrogen.

Supports Vaginal and Skin Comfort: Estriol is often favored for easing vaginal dryness and supporting skin elasticity.

Skin-Absorbed Dosing: Applied topically and absorbed through the skin, bypassing first-pass liver metabolism.

Personalized Strengths: Available in multiple concentrations so your clinician can tailor your dose.

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Benefits

Your body. Your personalized plan.

Hormonal changes don't have to mean feeling like a different person. Clinician-guided hormonal balance therapy and women's longevity protocols are built around your symptoms, your labs, and your phase of life.

Balance for every phase

Hormone protocols tailored to your phase of life, from perimenopause through menopause.

Bone Density Support

Estrogen protocols that help preserve long-term skeletal health and reduce fracture risk as you age.

Physician Supervised

Board-certified providers monitor your labs and adjust your protocol continuously — no one-size-fits-all dosing.

Protects long-term health

Estrogen protocols also support bone density and cardiovascular health.

Relief beyond hot flashes

Support for the mood, sleep, and metabolic shifts that come with menopause.

Weight Management

Hormonal support to combat the metabolic changes that come with perimenopause and menopause.

FAQs

Common questions, answered.

What is Biest 50:50?

Biest 50:50 is a compounded topical lotion that combines two forms of estrogen — estriol and estradiol — in a 50:50 ratio. It is applied to the skin as part of a personalized hormone therapy plan.

How do I apply Biest lotion?

Apply the measured dose to clean, dry skin such as the inner arm or inner thigh, rotate sites, let it absorb fully, and wash your hands. Avoid the breasts and irritated skin, and do not exceed the prescribed dose.

What strengths does Biest lotion come in?

Biest 50:50 lotion is available as 0.1% (delivering 0.25 mg or 0.5 mg per dose) and 0.2% (delivering 1 mg per dose). Your clinician selects the concentration and dose that fit your plan.

Is Biest FDA-approved?

Biest is a compounded medication prepared by a licensed compounding pharmacy for an individual patient. Compounded medications are not reviewed or approved by the FDA. It is dispensed only with a valid prescription following an individualized medical evaluation.

How do I get started with Biest lotion?

Start by completing a free online visit. An EOS Health-affiliated clinician reviews your symptoms, health history, and any lab work, then determines whether treatment is appropriate before writing a prescription. If prescribed, your medication ships to your door.

Biest 50:50 Topical Lotion