This medication is prepared by a licensed 503A compounding pharmacy and may only be dispensed pursuant to a valid, patient-specific prescription following an individualized medical evaluation. Compounded medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. Individual results vary.

EOS Women's Health

Estradiol Gel

Topical estradiol gel, personalized to your dose.

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110.00

Formulation

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Estradiol Gel is a topical 0.1% estrogen therapy applied to the skin once daily, where estradiol is absorbed transdermally for a needle-free alternative to patches or injections. It is used to relieve menopause symptoms such as hot flashes and night sweats and to support bone health, while skin absorption avoids first-pass liver metabolism. Your EOS Health-affiliated clinician selects the dose that fits your symptoms and lab work.

Available per-dose strengths: 0.25 mg / 0.5 mg / 0.75 mg / 1 mg / 1.25 mg

Key Features

Relieves Menopause Symptoms: Topical estradiol helps ease hot flashes, night sweats, and other symptoms of low estrogen.

Supports Bone Health: Restoring estrogen helps preserve bone density and slow post-menopausal bone loss.

Needle-Free Daily Application: A quick gel applied to the skin once a day — no injections or adhesives.

Skips the Liver: Skin absorption bypasses first-pass liver metabolism, which is associated with a lower clot risk than oral estrogen.

Flexible, Personalized Dosing: Available in a range of per-dose strengths so your clinician can fine-tune your dose.

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Benefits

Your body. Your personalized plan.

Hormonal changes don't have to mean feeling like a different person. Clinician-guided hormonal balance therapy and women's longevity protocols are built around your symptoms, your labs, and your phase of life.

Balance for every phase

Hormone protocols tailored to your phase of life, from perimenopause through menopause.

Bone Density Support

Estrogen protocols that help preserve long-term skeletal health and reduce fracture risk as you age.

Physician Supervised

Board-certified providers monitor your labs and adjust your protocol continuously — no one-size-fits-all dosing.

Protects long-term health

Estrogen protocols also support bone density and cardiovascular health.

Relief beyond hot flashes

Support for the mood, sleep, and metabolic shifts that come with menopause.

Weight Management

Hormonal support to combat the metabolic changes that come with perimenopause and menopause.

FAQs

Common questions, answered.

What is Estradiol Gel?

Estradiol Gel is a topical 0.1% gel that delivers estradiol, a form of estrogen, through the skin. It offers a needle-free daily application as part of a personalized hormone therapy plan.

How do I apply Estradiol Gel?

Apply the prescribed amount to clean, dry skin such as the upper arm or inner thigh once daily, let it dry fully, and wash your hands. Allow it to dry before dressing and avoid transferring it to others through skin contact.

What strengths does Estradiol Gel come in?

Estradiol Gel is available in per-dose strengths of 0.25, 0.5, 0.75, 1, and 1.25 mg. Your clinician selects the dose based on your symptoms and lab work.

Can the gel transfer to other people?

Yes. Estradiol can transfer through skin-to-skin contact, so let the gel dry completely, cover the area with clothing, and keep children and pets away from the application site.

How do I get started with Estradiol Gel?

Start by completing a free online visit. An EOS Health-affiliated clinician reviews your symptoms, health history, and any lab work, then determines whether treatment is appropriate before writing a prescription. If prescribed, your medication ships to your door.

Estradiol Gel