Estradiol transdermal systems require a valid prescription issued by a licensed clinician following an individualized medical evaluation. Use only as directed. Individual results vary.

EOS Women's Health

Estradiol Patch

Transdermal estradiol, applied twice weekly.

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72.00

/ month

90.00

Formulation

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The Estradiol Patch is a transdermal estrogen therapy worn on the skin and replaced twice weekly to deliver a steady stream of estradiol. It is used to relieve menopause symptoms such as hot flashes and night sweats and to support bone health, while its skin-absorbed delivery avoids first-pass liver metabolism. Your EOS Health-affiliated clinician selects the strength that fits your symptoms and lab work.

Available delivery rates: 0.025 mg/day / 0.0375 mg/day / 0.05 mg/day / 0.075 mg/day / 0.1 mg/day

Key Features

Relieves Menopause Symptoms: Transdermal estradiol helps ease hot flashes, night sweats, and other symptoms of low estrogen, with steady all-day delivery.

Supports Bone Health: Maintaining estrogen levels helps preserve bone mineral density and slow the bone loss that accelerates after menopause.

Steady, Twice-Weekly Dosing: The patch releases estrogen at a consistent rate and is changed only twice a week — no daily pill to remember.

Skips the Liver: Because it is absorbed through the skin, transdermal estradiol bypasses first-pass liver metabolism, which is associated with a lower clot risk than oral estrogen.

Better Sleep and Mood: By restoring estrogen balance, many women notice improvements in sleep, mood, and overall quality of life.

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Benefits

Your body. Your personalized plan.

Hormonal changes don't have to mean feeling like a different person. Clinician-guided hormonal balance therapy and women's longevity protocols are built around your symptoms, your labs, and your phase of life.

Balance for every phase

Hormone protocols tailored to your phase of life, from perimenopause through menopause.

Bone Density Support

Estrogen protocols that help preserve long-term skeletal health and reduce fracture risk as you age.

Physician Supervised

Board-certified providers monitor your labs and adjust your protocol continuously — no one-size-fits-all dosing.

Protects long-term health

Estrogen protocols also support bone density and cardiovascular health.

Relief beyond hot flashes

Support for the mood, sleep, and metabolic shifts that come with menopause.

Weight Management

Hormonal support to combat the metabolic changes that come with perimenopause and menopause.

FAQs

Common questions, answered.

What is the Estradiol Patch?

The Estradiol Patch is a transdermal system that delivers estradiol, a form of estrogen, through the skin at a steady rate. It is worn on the skin and replaced twice weekly as part of a personalized hormone therapy plan prescribed by a licensed clinician.

How do I use the Estradiol Patch?

Apply the patch to clean, dry skin on the lower abdomen or hip, press firmly for about 10 seconds, and replace it twice weekly following your clinician's schedule. Rotate application sites and avoid the breasts and any irritated skin.

What strengths does the Estradiol Patch come in?

The patch is available in delivery rates of 0.025, 0.0375, 0.05, 0.075, and 0.1 mg per day. Your clinician selects the strength that fits your symptoms and lab work.

Do I also need progesterone with the patch?

If you still have a uterus, estrogen is generally prescribed together with a progestogen such as progesterone to help protect the uterine lining. Your clinician will advise whether a combination plan is right for you.

How do I get started with the Estradiol Patch?

Start by completing a free online visit. An EOS Health-affiliated clinician reviews your symptoms, health history, and any lab work, then determines whether treatment is appropriate before writing a prescription. If prescribed, your medication ships to your door.