Estradiol vaginal cream requires a valid prescription issued by a licensed clinician following an individualized medical evaluation. Use only as directed. Individual results vary.

EOS Women's Health

Estradiol Vaginal Cream

Localized estrogen for vaginal comfort.

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Estradiol Vaginal Cream is a low-dose, locally applied estrogen therapy used to relieve the genitourinary symptoms of menopause — including vaginal dryness, irritation, painful intercourse, and related urinary symptoms. Applied vaginally, it restores local tissue with minimal systemic absorption. Your EOS Health-affiliated clinician determines the amount and schedule that fit your needs.

Available strength: 0.1 mg/g estradiol (0.01%) · 42.5 g tube

Key Features

Relieves Vaginal Dryness: Low-dose estradiol restores vaginal and vulvar tissue to ease dryness, irritation, and itching.

Eases Painful Intercourse: By rebuilding thinned tissue and normalizing pH, it can reduce discomfort during intimacy.

Supports Urinary Comfort: Local vaginal estrogen may help with urinary frequency and recurrent urinary tract infections.

Acts Locally: Delivers estrogen right where it is needed, with minimal systemic absorption.

Flexible Application: Applied with a measured applicator on a schedule your clinician sets.

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Benefits

Your body. Your personalized plan.

Hormonal changes don't have to mean feeling like a different person. Clinician-guided hormonal balance therapy and women's longevity protocols are built around your symptoms, your labs, and your phase of life.

Balance for every phase

Hormone protocols tailored to your phase of life, from perimenopause through menopause.

Bone Density Support

Estrogen protocols that help preserve long-term skeletal health and reduce fracture risk as you age.

Physician Supervised

Board-certified providers monitor your labs and adjust your protocol continuously — no one-size-fits-all dosing.

Protects long-term health

Estrogen protocols also support bone density and cardiovascular health.

Relief beyond hot flashes

Support for the mood, sleep, and metabolic shifts that come with menopause.

Weight Management

Hormonal support to combat the metabolic changes that come with perimenopause and menopause.

FAQs

Common questions, answered.

What is Estradiol Vaginal Cream?

Estradiol Vaginal Cream is a low-dose estrogen cream applied vaginally to relieve the genitourinary symptoms of menopause, such as vaginal dryness, irritation, and painful intercourse. It acts locally with minimal systemic absorption.

How do I use Estradiol Vaginal Cream?

Use the measured applicator to insert the prescribed amount vaginally, usually at bedtime, on the schedule your clinician sets. Wash the applicator and your hands after each use.

What strength and size does the cream come in?

The cream contains 0.1 mg of estradiol per gram (0.01%) and comes in a 42.5 g tube with a measured applicator.

Does the vaginal cream affect the rest of my body like pills or patches?

Vaginal estrogen acts mainly on local tissue, and studies show minimal systemic absorption at low doses. Your clinician will review your health history to confirm it is appropriate for you.

How do I get started with Estradiol Vaginal Cream?

Start by completing a free online visit. An EOS Health-affiliated clinician reviews your symptoms, health history, and any lab work, then determines whether treatment is appropriate before writing a prescription. If prescribed, your medication ships to your door.

Estradiol Vaginal Cream