Compounded by a U.S.-licensed pharmacy following an individualized medical evaluation; not reviewed or approved by the FDA for safety or effectiveness. Intended for topical skin-support use. Avoid application on broken or compromised skin and discontinue if irritation develops. Individual results vary.

EOS Skin

GHK-Cu Cream

Collagen, repair, and tone — at the dermis level.

From

A physician-formulated copper peptide cream built around GHK-Cu (copper tripeptide-1), a naturally occurring complex the skin produces less of with age. Applied topically, it signals the skin to rebuild — supporting collagen and elastin, reinforcing the moisture barrier, and helping to firm and smooth over time.

GHK-Cu has decades of dermatologic research behind it, with studies showing improvements in skin density, firmness, fine lines, and tone. Formulated for nightly use, it works on its own or alongside a retinoid protocol — for members focused on long-term skin health rather than quick fixes.

Key Features

Rebuilds Collagen & Elastin: GHK-Cu signals fibroblasts to produce the structural proteins that keep skin firm, helping to soften fine lines and restore bounce.

Repairs & Renews: Originally studied for wound healing, copper peptides accelerate the skin's natural repair pathways — supporting recovery from sun damage and everyday wear.

Evens Tone & Texture: Regular use helps fade hyperpigmentation and refine surface texture for a smoother, more uniform complexion.

Strengthens the Barrier: Reinforces the skin's protective layer to improve moisture retention and reduce age-related sensitivity.

Antioxidant Defense: Delivers trace copper that helps neutralize the oxidative stress of daily environmental exposure.

Gentle Enough for Nightly Use: A well-tolerated, non-retinoid active that pairs easily with the rest of a routine.

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Benefits

Science your skin can feel.

The best skincare isn't trend-driven — it's evidence-driven. Our physician-curated formulations are designed for long-term skin health, not quick fixes.

Evidence over trends

Physician-curated formulations built for long-term skin health, not fads.

Visible change over time

Most people see visible change in 4–8 weeks, with structural change over months.

Works at the dermis

Topical peptides and clinical-grade retinoids support collagen, firmness, and texture.

FAQs

Common questions, answered.

What is GHK-Cu?

GHK-Cu, or copper tripeptide-1, is a small copper-binding peptide that occurs naturally in the body. Levels are highest in youth and decline with age. Applied topically, it acts as a signal that tells skin cells to repair and regenerate — which is why it's become one of the most studied ingredients in skin longevity.

What does GHK-Cu cream do for my skin?

It supports collagen and elastin production for firmer skin, helps smooth fine lines, reinforces the moisture barrier, and can improve tone and texture over time. Copper peptides were first studied for wound healing, so a hallmark of GHK-Cu is its support for the skin's natural repair process.

How do I use it, and when will I see results?

Apply a thin layer to clean, dry skin, typically at night. Most people use it once daily. As with most evidence-based skincare, visible change is gradual — many notice improvements in tone and smoothness within 4–8 weeks, with firmness and fine-line changes developing over several months of consistent use.

Can I use GHK-Cu with retinoids or vitamin C?

GHK-Cu pairs well with most routines and is often layered with retinoids on alternating nights or in a separate step. There's longstanding debate about combining copper peptides with high-strength vitamin C in the same application, so many providers suggest using them at different times of day. Your EOS clinician can tailor a routine to the actives you already use.

Is GHK-Cu cream safe? Are there side effects?

Topical GHK-Cu is generally well tolerated. Some people experience mild, temporary redness or irritation, especially when first starting. It is intended for topical use only and should not be applied to broken or compromised skin. If you're pregnant, nursing, or have a known copper sensitivity, review this with your clinician before starting. Full details are in the Important Safety Information.

Who is GHK-Cu cream best for?

It's a strong fit for adults focused on long-term skin health — those wanting to support collagen, soften early signs of aging, even tone, and strengthen the skin barrier. It's also a gentler, non-retinoid option for people whose skin doesn't tolerate stronger actives well.