Important Safety Information

Estradiol Patch — Important Safety Information

Important safety information for the estradiol transdermal patch — how to apply, estrogen-related warnings, side effects, and precautions.

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Estradiol transdermal systems are prescription products dispensed following an individualized medical evaluation by a licensed clinician. This summary does not replace guidance from your prescribing clinician.

How to use

  • Apply the patch to clean, dry, intact skin on the lower abdomen or hip, exactly as prescribed. Replace it twice weekly on the schedule your clinician gives you.
  • Press the patch firmly in place for about 10 seconds and rotate application sites with each change.
  • Do not apply to the breasts, or to skin that is oily, broken, irritated, or recently shaved.
  • Do not use more patches or change them more often than prescribed.

Before you start

  • Tell your clinician about your full medical history, allergies, and all medications and supplements you take.
  • Do not use if you are pregnant, may be pregnant, or are breastfeeding.
  • Share any history of blood clots, stroke, heart attack, breast or uterine cancer, liver disease, or unexplained vaginal bleeding.

Important warnings

  • Estrogens may increase the risk of blood clots, stroke, and certain cancers. When you have a uterus, estrogen is generally prescribed together with a progestogen to help protect the uterine lining.
  • Do not smoke while using estrogen — smoking raises the risk of serious cardiovascular events.
  • Seek emergency care (call 911) for sudden chest pain, shortness of breath, pain or swelling in a leg, sudden severe headache, vision changes, or weakness, numbness, or trouble speaking.

Possible side effects

  • Skin redness or irritation at the patch site, breast tenderness, headache, nausea, bloating, fluid retention, mood changes, or vaginal spotting.
  • Report any unusual or persistent side effects to your clinician promptly.

Precautions

  • Store as directed and keep out of reach of children and pets. Fold used patches closed before discarding.
  • Do not stop or change your dose on your own — follow your clinician's guidance.

You are encouraged to report negative side effects of prescription products to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. Please reach out to your EOS Health-affiliated provider if you have any questions or concerns.

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You are encouraged to report negative side effects of prescription products to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.