Estradiol Tablets — Important Safety Information

How to use

• Take one tablet by mouth once daily, exactly as prescribed — ideally at the same time each day, with or without food.
• If you still have a uterus, take the progestogen (such as progesterone) your clinician prescribes alongside estrogen.
• Do not take more than prescribed or stop suddenly without speaking to your clinician.

Before you start

• Tell your clinician about your full medical history, allergies, and all medications and supplements you take.
• Do not use if you are pregnant, may be pregnant, or are breastfeeding.
• Share any history of blood clots, stroke, heart attack, breast or uterine cancer, liver disease, or unexplained vaginal bleeding.

Important warnings

• Estrogens may increase the risk of blood clots, stroke, and certain cancers. When you have a uterus, estrogen is generally prescribed together with a progestogen to help protect the uterine lining.
• Do not smoke while using estrogen — smoking raises the risk of serious cardiovascular events.
• Seek emergency care (call 911) for sudden chest pain, shortness of breath, pain or swelling in a leg, sudden severe headache, vision changes, or weakness, numbness, or trouble speaking.

Possible side effects

• Nausea, breast tenderness, headache, bloating, fluid retention, mood changes, or vaginal spotting.
• Report any unusual or persistent side effects to your clinician promptly.

Precautions

• Store as directed and keep out of reach of children. Do not stop or change your dose on your own.

You are encouraged to report negative side effects of prescription products to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

This information is not comprehensive. Please reach out to your EOS Health-affiliated provider if you have any questions or concerns.